ABCC11 ATP binding cassette subfamily C member 11 [Homo sapiens (human)] - Gene - NCBI ABCC11 ATP binding cassette subfamily C member 11 [Homo sapiens (human)] - Gene - NCBI

Abcc11 gene asian dating, lovd - leiden open variation database

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However, three quarters of those who do not produce an odour regularly use deodorants; we believe that these people simply follow socio-cultural norms. Demographics[ edit ] The history of the migration of humans can be traced back using the ABCC11 gene alleles. So I looked it up. Human earwax, a secretory product of the ceruminous apocrine glands, is classified into wet and dry types.

Histological images of human apocrine glands [ 1 ] were analyzed by the ImageJ program v1. Across most cultures, body odor is often perceived as being unpleasant by other persons, whereas it also affects the confidence and self-esteem of the person emitting the odor.

In contrast the relationship within Asian populations is weaker.

Koreans born to be odorless: research

Earwax and body odor There are two kinds of sweat glands: Annals of Human Genetics As a abcc11 gene asian dating, no granular or vacuolar localization was detected in the cerumen apocrine glands of people homozygous for the SNP variant.

There are, however, two problems with using earwax type in classroom exercises. To address this problem, mankind has developed ways and means to manage body odor, for example, by the use of deodorants, refreshing sprays, and perfumes.

Interestingly, this association had already been pointed out in chidinma and flavour dating divas middle of the 20th century [ 1415 ]. Although the biochemical and physiological pathways that regulate the apocrine secretory process are not clearly known, our recent findings Yoshiura et al.

Therefore, in the clinical setting, rapid, simple, and cost-effective methods are required for on-demand genotyping. It is well known that on average Africans are more diverse than non-Africans, probably because the latter are a sampling of the former, but, on a small minority of genes the reverse is true.

Earwax as a character

Based on the geographical gradient distribution of the A allele with a peak in East Asia, especially in Northern China and Korea, one might assume that the c.

Ectopic expression of ABCC11 in mammalian cells enhances the cellular efflux of cyclic nucleotides and confers resistance to certain anticancer and antiviral nucleotide analogs Guo et al. It has also been shown by a Japanese research group that the expression of ABCC11 in women with breast cancer is associated with aggressive phenotypes and poor disease-free survival [ 44 ].

The wet type of earwax is derived from the secretion product of the apocrine gland in the external auditory canal, whereas this apocrine secretion is lacking in the dry-type phenotype.

ABCC11 - Wikipedia

A functional ABCC11 allele is essential in the biochemical formation of human axillary odor. He found a higher frequency of wet earwax in Japanese-American women with breast cancer than in a control group of Japanese-American women, although the difference was not statistically significant. The hitchhiking process means that within a population you may see regions of the genome which exhibit long sequences of correlated single-nucelotide polymorphisms SNPshaplotypes.

Therefore, there has been a need for objective evidence for diagnosis of axillary osmidrosis to prevent unnecessary treatments for such patients.

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Efficient quality control systems have evolved to prevent incompletely folded proteins from moving along the secretory pathway. And this is clearly true for rs; most non-African populations exhibit some heterozygosity.

Yasuo Sakai Osaka University for their helpful discussions about the relationship between ABCC11 genotype and axillary osmidrosis risk. The extent and decay of LD then can help us gauge the time and strength of selection events.

Chemical structures of compounds underlying human axillary odor. In humans, however, strong or specific body odors are sometimes considered to be unpleasant.


Historical overview on identification of the ABCC11 gene and its function. Whilst the routes of migration followed by the ancient Mongoloid people remain obscure, two different routes have been proposed Figure 3B. The variants which are nearly fixed in East Asia around this locus are nearly disjoint in frequency with those in Africa.

In this context, the development of new technologies for simple, fast, accurate, and cost-effective genotyping is imperative. Although the odor does not affect health, axillary osmidrosis AO is a condition in which an individual feels uncomfortable with their axillary odor, regardless of its strength, and may visit a hospital.

The major findings of this paper beyond what was known before seem to be a an explicit model of how East Asians could have arrived at a high frequency of the AA genotype at rs, and, b the correlation between climate and the frequency of A.

Therefore, it is suggested that genotyping of the ABCC11 gene would provide an accurate and practical criterion for guidance of appropriate treatment and psychological management of patients Toyoda et al.

ATP-binding cassette sub-family C member 11

The reality is that much of China, Korea and Japan are subtropical today. Sweat produced by the axillary apocrine glands is odorless. Breast Cancer Research and Treatment It is likely that the product of the SNP variant Arg is recognized as a misfolded protein in the ER and readily undergoes proteasomal degradation.

Genetic polymorphisms associated with potential risks of various human genetic diseases as well as drug-induced adverse reactions have recently been well studied, and their underlying molecular mechanisms are being uncovered by functional genomics as well as genome-wide association studies.

Why the Chinese don’t buy deodorant

This scheme is modified from Toyoda et al. As such evidence accumulates, new clinical applications and practices are needed. Eccrine sweat glands produce sweat that is mostly water and salt, and it does not contribute very much to body odor.

Remember that heterozygosity tends not to go above 0. Similar geographic distribution and ethnic differences are known for the ALDH2 gene, one of the major determinants for alcohol sensitivity Goedde et al. Axillary osmidrosis, which is exemplified by unpleasant odors, sweating and staining of clothes, is often perceived, especially by young women, as a distressing and troublesome problem Wu et al.

Family studies

This genotyping-based strategy would be helpful in making the diagnosis of axillary osmidrosis, since the objective evidence acquired would relieve ORS patients of their odor delusion. A simple gene test might strengthen self-awareness and save some unnecessary purchases and chemical exposures for non-odour producers.

Distribution and inheritance of earwax types: ORS patients tend to hope that surgical resection of the axillary apocrine glands will fundamentally resolve their problem, even if this is contrary to the clinical judgment of the doctor.

Morphological differences were previously reported between the secretory cells of wet and dry types of human ceruminous glands Shugyo et al. Further clinical studies, including protein expression studies in tumors, will be needed to clarify the potential contribution of ABCC11 to breast cancer risk and prognosis, including drug resistance and chemosensitivity.

This study looked for the first time at deodorant usage in relation to ABCC11 genotype and also in comparison with other factors such as age, background and general household hygiene.